Please refer to this article for all M-Audio hardware and software compatibility with macOS 12 Monterey.
We encourage all our users to remain on their current OS until all necessary hardware and software products have been qualified for use with the macOS Monterey operating system. We understand how important it is for all our users to know exactly what works before they make the jump on any new updates. M-Audio has been actively testing all applicable hardware and software products with each beta release of macOS 12 Monterey.
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